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The interest to investigate the role of Vitamin E in AD is supported by lower levels of vitamin E in AD patients (81, 82)

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Crucially, besides inducing membrane depolarization through 7nAChR-gated Ca2+ conductance, there is growing evidence suggesting potential metabotropic activities of this ionotropic receptor [43]

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We then asked whether changes in the SNc and ventral tegmental area (VTA) regions, the primary sources of striatal DA, led to elevated striatal TH expression and DA levels