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SGLT2 inhibitors attenuate oxidative stress through multifaceted mechanisms encompassing glucotoxicity reduction and mitochondrial functional enhancement (308)

avoidance recommended as a precaution Active malignancy: Pro-angiogenic mechanism warrants caution until more data is available History of hormone-sensitive cancers: Discuss thoroughly with your physician Severe coagulation disorders: Given vascular effects, clinical assessment required Patients on certain anticoagulants: Monitoring required

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Protein Cell 12:599620 Sui X, Zhang R, Liu S, Duan T, Zhai L, Zhang M, Han X, Xiang Y, Huang X, Lin H et al (2018) RSL3 drives ferroptosis through GPX4 inactivation and ros production in colorectal cancer