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[6] [42] [43] For single doses of lipophilic, multi-compartment drugs, clinical duration after onset is often driven by the distribution () phase, because by the time distribution equilibrium is reached plasma levels are frequently below any minimal effective concentration, so the terminal phase has little bearing on observable effects
Holland D, Ben-Hayyim G, Faltin Z, Camoin L, Strosberg AD, Eshdat Y (1993) Molecular characterization of salt-stress-associated protein in citrus: protein and cDNA sequence homology to mammalian glutathione peroxidases
The procedure is carried out in a hospital under general anesthesia