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While cysteine, which is formed by the transsulfuration pathway from homocysteine and is therefore an indirect measure of the function of the methionine cycle, glutathione formation requires additional steps for its formation and is not directly a component of the cycles related to S-adenosyl methionine

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The toxicity studies with repeated doses for 69 months in rat, mice and dogs exhibited no major toxicity in organs

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Not only are these antivirals not effective against this latent HSV reservoir, but they also arent a perfect treatment for flare-ups, either: they must be taken consistently at large doses, often fail to adequately control symptoms, and become ineffective in an increasing number of patients who are developing resistance