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Homocysteine, a risk factor for cardiovascular disease, interferes with the translational reading of SECIS in the expression of GPx1 [53] and, therefore, inhibits the expression of GPx1 promoting the increase of oxygen species reagents that inactivate nitric oxide and cause endothelial dysfunction

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Furthermore, IL-6 has multiple functions, among them its ability to regulate immune responses

Due to high patient demand, vitamin supplements, antioxidants, and minerals such as biotin, zinc, copper, selenium, and calcium pantothenate are frequently used, although their efficacy has not been demonstrated