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The modularity of ROSALIND has permitted the development of transcriptional circuits controlled not only by metallosensors, including SmtB (Zn II ), CsoR (Cu/Zn II ) and CadC (Pb II /Cd II ), but also those capable of detecting small organic molecules, such as TetR (tetracycline), MphR (erythromycin) and QacR (benzalkonium chloride)