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Notably, in models of type 2 diabetes, PCs confer neuroprotection by modulating NF-E2/STAT1 signaling, attenuating Janus kinase activity, and inhibiting cell apoptosis, thereby reducing cerebrovascular lesions and associated neurological deficits (Wu et al., 2015

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He notes that many shamanic traditions do not rely on psychedelics at all, and that rhythmic music, drumming, dance, and social ritual can reliably produce trance states