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Keywords: roflumilast, methotrexate, hepatotoxicity, glutathione, malondialdehyde, tumor suppressor protein-53, interleukin 6, interleukin 1 Introduction Drug-induced liver toxicity is a major limitation of pharmacotherapy, which can lead to fatal adverse drug reactions and incidence of morbidity and mortality

129,130 During the general development of the fetal liver, the originally expressed MAT2A is gradually replaced by MAT1A

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