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The geometries of the refined structures were analyzed and validated using MolProbity 36

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In cell cultures, the bpc 157 peptide angiogenesis pathway functions primarily by stimulating the phosphorylation of VEGFR2

These observations strongly support the current hypothesis that reactive metabolite formation and protein binding especially in mitochondria are the key initiating events in the toxicity, which is then the trigger for a moderate mitochondrial oxidant stress with release of superoxide by complex III towards the cytosol without compromise of mitochondrial respiration [33]

Authors contributions Analysis & interpretation of data (PJ, EB, ML), statistical analysis (PJ, EB, ML), manuscript writing (PJ, ML), critical revision (EB, ZY, MV, ML), material support (MV).