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Transmembrane protease serine 2 (TMPRSS2) facilitates virus-cell membrane fusion (Zlack et al., 2021)

Effects of acute and chronic oxidative stress on the blood-brain barrier in 2D and 3D in vitro models

Based on experiments with this organoid model of small airway epithelia, and comparisons with 16HBE14o- and other cell types expressing normal CFTR, we predict that inflammation in the COVID-19 airway may be mediated by inhibition of CFTR signaling by the SARS-CoV-2 spike protein, thus inducing a cystic fibrosis-like clinical phenotype

Also, measurement of 5-oxoproline levels in blood or urine is indicated to identify the interaction of these two drugs with certainty and to have insight into the severity of the accumulation

Conclusion This study screened 78 different Chinese herbal plants and identified the potent and functional components useful for tyrosinase inhibition, melanogenic inhibition and depigmentation