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Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes

The animal experiments were approved by the Animal Ethics Committee of Tianjin Medical University and Welfare Committee

Such dynamic adjustments, driven by real-time microbiome data, offer the potential to optimize therapeutic outcomes and minimize the adverse effects of treatment

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As cartilage thins, pain, stiffness, and swelling follow particularly with weight-bearing activity