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A recent meta-analysis including five studies evaluating NAC and 574 patients with depression (291 randomized to NAC and 283 to placebo) with a follow-up of 1224 weeks revealed significantly greater improvements in depressive symptoms (MADRS) and functionality with NAC than with placebo [143]

"Metoprolol: Uses, Dosage, Side Effects"

Third, the substrate may be converted to a free radical, as in the case of carbon tetrachloride

Exp Toxicol Pathol 63:6978 Hu Y, Shen Y, Li Y (2015) Effect of Pin1 inhibitor juglone on proliferation, migration and angiogenic ability of breast cancer cell line MCF7Adr