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Chronic use has been associated with withdrawal symptoms, including heightened anxiety, depressive-like behaviors, increased cortisol levels, and oxidative stress

Basic properties and clinical applications. Expert Opinion on Biological Therapy, 12(1), 3751

the broad, gradual nature of the loss over a wide temperature range suggests decomposition/char formation of the confined organic species and strong hostguest interactions or confinement effects that spread the decomposition process to high temperature

"About 3mL" is not 3mL

NICE notes that pernicious anaemia is the most common cause of Vitamin B12 deficiency in those aged 40-70, with an average onset age of 60 in white people and 50 in black people, although it can affect black women at a younger age