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GraphPad Prism was used to calculate the area under the curve (AUC) for both parameters with or without 5FU, and then the difference in AUC was calculated as (AUC +5FU) (AUC 5FU)

The results revealed that the mRNA expression levels of BZLF1 and BRLF1 were significantly greater than those of the negative control group after treatment with erastin, which also validated the same conclusion (Fig

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This inhibitory effect may lead to increased immunosuppression in the tumor microenvironment, which in turn affects the effectiveness of the overall immune response (65, 66)