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High-dose oral supplementation may be another treatment option, because consuming 1,000 g (1 mg) per day of vitamin B 12 orally should result in the absorption of about 10 g/day (1% of dose) by passive diffusion
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The ratio is heavily weighted toward NAD+, with the two metabolic compounds dosed at a tenth of that each
doi: 10.2337/diabetes.53.9.2242
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