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The mechanism involves upregulation of matrix metalloproteinases (MMPs) and their inhibitors, which remodel collagen in a more organized way than unassisted healing

Belinostat, a hydroxy acid pan-HDAC, for the treatment of multiple cancers (31)

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Specifically, the generation of data on AITC homology modeling with human ingestion of mustard proteins is crucial (not done here) for deeper analysis of the largely unknown biochemical interactions, and also field trials to assess the efficacy of AITC and mustard oils against global insect pests are urgently needed

Injectable routes carry a particular concern for immunogenicity from peptide aggregation and impurities, and FDA noted the available certificates of analysis for AOD-9604 bulk drug substances did not consistently control for impurities, aggregates, or microbial limits