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The short half-life of native GLP- 1-based therapy in the circulation (approximately two minutes after intravenous administration and one to five hours after subcutaneous administration) posed a problem during its early development [9]

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Cardiometabolic syndrome: pathophysiology and treatment

After intravenous administration, in agreement with a previous report (25), most of the GSH was oxidized to GSSG and disappeared immediately from circulation with a half-life of about 10 min

Together, these residues create a hybrid framework combining aromatic and hydrophobic regions within a multi-amide backbone