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It is prescribed off-label based on clinician judgment and emerging research

It is well established that the intrinsic variation in the core microbiota composition across individuals (inter-individual variation) is important and it is therefore difficult to draw significant conclusions on studies investigating a limited number of participants 4,6

10.1038/s41467-022-32085-7

A summary of the effects of diet (D), sex (S) and their interaction (DxS) for each gene separately is provided in Fig

Additionally, another SOD mimic, GC4419, 580 has demonstrated good safety in phase II clinical trials among head and neck cancer patients suffering from severe oral mucositis induced by radiation and chemotherapy (NCT02508389)