Factors such as heterogeneous clinical manifestations, geographic dispersion, limited patient numbers and high disability rates exacerbate these challenges
Detoxification: Heavy metals and toxins are bound by glutathione, which makes it easier for the body to expel them
New York: Academic Press
2.1 Cisplatin-induced DNA damage and apoptosis Once cisplatin enters the cell it can be hydrolyzed to form toxic aqua-cisplatin complexes and form intra-and interstrand crosslinks with DNA (Johnstone et al., 2016), the formation of such DNA adducts induces structural distortions of the DNA helix, which in turn leads to DNA damage, which activates multiple signaling pathways, one of which is the activation of the ATM-Chk2-p53 pathway (Benkafadar et al., 2017)
For specific needs, explore glutathione during pregnancy safety, alcohol interaction guidelines, or injection protocols