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Inhibition of fibroblast growth factor receptor 4 significantly reduces glutathione synthesis, leading to excessive ROS production and unstable iron pool accumulation, which triggers ferroptosis to overcome drug resistance of HER2-positive breast cancer (144)
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Peter Attia Peter Attia, M.D., completed his medical and advanced training at Stanford University School of Medicine, Johns Hopkins School of Medicine and the National Institutes of Health (NIH)