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833 Urease adopts a C3-symmetric trimer of trimers () architecture (Figure 39A), harboring a buried binuclear Ni 2 active site (Figure 39B) featuring a bridging carbamylated Lys (Figure 39C), with all metal ligands derived from the -subunit

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At 12 mg, the trajectory suggests sustained loss well beyond the point where tirzepatide users at 15 mg have already plateaued