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These additional excretion pathways collectively contribute to maintain TMAO balance in the body ( In summary, TMAO metabolism involves converting dietary choline to TMA by gut microbes, oxidizing TMA to TMAO in the liver, and primarily excreting TMAO via the kidney, with minor elimination through sweat, feces, and breath

Figure 1: The representative model of interrelationships within the GH neuroendocrine axis 8

Arginine and lysine strongly favor guanine base while asparagine and glutamine prefer adenine