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Rationale for targeting 7nAChR in ASD Postmortem examination of individuals with ASD has revealed abnormalities in cholinergic nuclei, cholinergic projections, cholinergic receptors, and growth factors responsible for the development and upkeep of cholinergic neurons [22]

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The deletion strains for genes encoding these enzymes were sensitive to 5-OP while overexpression of YHR033w, KDX1 and OSI1 confers a resistance to 5-OP toxicity in oxp1 strain as well as their respective deletion strains (Fig 2D, E)