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Sonia Alcal, Department of Biochemistry, Autnoma University of Madrid, Instituto de Investigaciones Biomdicas "Alberto Sols" CSIC-UAM, Madrid 28029, Spain

Tang, Q., Tan, P., Ma, N., & Ma, X

Dimensions: 7771 x 4498 px | 65.8 x 38.1 cm | 25.9 x 15 inches | 300dpi Date taken: 29 June 2020 Photographer: MOLEKUUL/SCIENCE PHOTO LIBRARY

Trypsin was set as the digestion enzyme

Nowadays, the regimens of cancer therapy, such as surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, aim to induce the death of cancer cells to achieve a therapeutic effect, whereas the intrinsic and acquired resistance of cancer cells to cell death often results in far from satisfactory treatment outcomes (Loftus et al., 2022