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Trim22 inhibits osteosarcoma progression through destabilizing nrf2 and thus activation of ros/ampk/mtor/autophagy signaling

A study demonstrated that prebiotics, particularly fructooligosaccharides (FOS) and galactooligosaccharides (GOS), enhance the gut microbiota of high-fat diet (HFD)-fed mice by increasing acetate-producing bacteria, such as Bacteroides acidifaciens and Phocaeicola dorei (basonym Bacteroides dorei ), improving intestinal permeability, upregulating neurogenesis and synaptic plasticity-related markers (PSD, SAP 102, CREB-p, and BDNF), promoting brain acetate and GPR43 levels while reducing pro-inflammatory cytokines, and positively influencing neuronal proliferation and survival signaling in the hippocampus and prefrontal cortex ( Bacillus subtilis var

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