Even moderate alcohol intake measurably lowers hepatic glutathione because ethanol metabolism produces acetaldehyde, a toxic intermediate that glutathione has to neutralize
5.4 Toxic diffuse goiter (Graves disease) In Graves Disease (GD) and its ocular manifestation, Graves Orbitopathy (GO), ferroptosis affects cell metabolism and iron balance
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PC, an irreversible oxidative modification (88), is classified into two types based on the origin of the carbonylated product (Figure 2)
Experimental example Using erastin-treated A549 cells, we measured intracellular Fe 2+ , ROS, lipid peroxide, glutathione, glutamate release into the extracellular space, and cystine uptake