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Men and women 60 years or older have average dietary intakes of 5.6 g/day and 3.7 g/day, respectively (126)

Patients receiving B12 injections should inform their healthcare provider of all medications, as certain drugs (including metformin, proton pump inhibitors, and chloramphenicol) can affect B12 absorption or metabolism

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The metabolic adaptations that occur are limited to the enhanced expression of beta-3 adrenergic receptors in adipose tissue, which actually represents a favorable metabolic improvement rather than a dependence-creating change