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Therefore, as a result, oxidative stress is related to several chronic diseases such as cancer, diabetes, CVD (Reference Romero Cabrera15Reference Fridovich17) and some neurodegenerative disorders (such as Alzheimers disease or Parkinsons disease) (Reference Chen, Guo and Kong18) .The function of the antioxidant defense system of the body is to prevent any damage due to the action of free radicals (Reference Uttara, Singh and Zamboni19)

The advice to separate them by AM and PM exists for this reason

The disruption of Ca 2+ homeostasis resulting from alteration of Ca 2+ channels/transporters/pump activities plays a major role in tumor initiation, development, angiogenesis, and metastasis [83]

Although direct inhibition of mGPD2 remains debated (Figure 2) (LaMoia et al., 2022)