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Ferroptosis serves as a promising target for CRC treatment Studies have demonstrated that ferroptosis is mainly regulated by the metabolism of amino acid, lipid and iron [26]

Secondary structural elements included -helices (labeled H1, H2, etc., depicted as purple cylinders), -sheets (strands labeled A, B, etc., shown as purple arrows), and conformational motifs (-turns, -turns, and -hairpins)

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The 28-day mortality rate was collected and calculated by follow-up of patients after intervention by telephone contacting their families

Acknowledgments Thanks to GAIN (Axencia Galega de Innovacin) for supporting this research (grant number IN607A2019/01)