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After OGD treatment, the number of Ki-67-positive endothelial cells significantly decreased, while the intracellular expression levels of senescence markers P21, P53, and the DNA damage indicator -H2AX were markedly elevated (Figure 3B)

What differs is the second (and third) pathway each adds: CagriSema adds amylin, tirzepatide adds GIP, retatrutide adds both GIP and glucagon

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"The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system." Journal of Pharmacology and Experimental Therapeutics

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