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Lab Investig 81:11851190 Verzola D, Gandolfo MT, Ferrario F, Rastaldi MP, Villaggio B, Gianiorio F, Giannoni M, Rimoldi L, Lauria F, Miji M, Deferrari G, Garibotto G (2007) Apoptosis in the kidneys of patients with type II diabetic nephropathy

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Body composition changes (fat loss or lean mass gain) are described in case reports and small trials but are not consistently replicated in larger, controlled cohorts

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There may be times (like during other illnesses or infections) when the body naturally uses more energy, and these should be managed quickly and effectively