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In our study, the upregulated metabolites of 1-methylxanthine, 7-methylxanthine, and theobromine, as well as downregulated caffeine, in the HN versus LN groups, resulted in enriching caffeine metabolism, suggesting that caffeine metabolism exhibited marked changes in the LN group

Despite a slowdown of economic growth in China that has resulted in near-saturation of cigarette sales in the country, slim cigarette production and marketing as a new point of growth for the tobacco industry face a rare period of opportunities for development

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