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Although this is consistent and mechanistically validated across different preclinical models, as reviewed in the Preclinical and clinical applications of NAD + -modulating interventions for mitochondrial homeostasis and health benefits section, the correspondence between NAD + changes and mitochondrial or metabolic alterations is more complex in human studies

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[47] Oxidoreductase binding of NAD [edit] The main role of NAD + in metabolism is the transfer of electrons from one molecule to another

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Humanin is another mitochondrial-derived research peptide discussed around cytoprotection, apoptosis regulation, and cellular stress response