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Mechanistically, the increase in CHAC1 expression in cancer cells can be linked to the induction of ferroptosis through the ATF4 mediated UPR branch (Wang et al., 2021)

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Thus, it is suggested to apply the term iron overload-driven cell death. Morphological signs of eryptosis Eryptosis is characterized by a wide array of morphological alterations, which generally coincide with those observed in apoptotic cells [84]