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A transglutaminase derived from Streptomyces mobaraensis catalyzes transpeptidation where a primary amine-containing linker is covalently attached to the primary amide side chain of a specific glutamine (Q295) within deglycosylated antibodies, resulting in ADCs with a defined DAR of 2 (one conjugation site per heavy chain) (Jeger et al., 2010

Author contributions XZ: Methodology, Validation, Conceptualization, Investigation, Writing original draft, Formal Analysis

Support of Cellular Longevity and Mitochondrial Function In animal studies, prolonged administration of Epithalon was associated with increased lifespan and improved markers of physiological function in aging rodents

Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, Zabezhinski MA, Alimova IN, Baturin DA, Zavarzina NY, Rosenfeld SV, Semenchenko AV, Yashin AI

Chen L, Guo Y, Wu ZZS, Zhang Z, Zheng F,Sun L,Hao Z,Xu C,Wang T, Peng Y