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Microbiota-targeted interventions, including probiotics, prebiotics, synbiotics, and dietary modulation, have demonstrated potential to improve microbial composition, alleviate systemic inflammation, enhance thyroid hormone utilization, and reduce autoantibody levels

10.1155/2013/162750 81 KurutasE

The methods can be separative and non-separative

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CRL4, similar to other CRLs, are modular complexes, comprising a core formed by the cullin scaffold (CUL4A or CUL4B) and a catalytic RING domain subunit (RBX1)