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Other studies such as Schalka et al have reported that continued use of Polypodium leucotomos is effective in increasing individual resistance to UV-induced pigmentation and erythema and thus might be useful in treating pigmentary disorders

This inherent stability is a critical factor in why it's a candidate for oral and intranasal delivery, where it would encounter harsh environments

Journal of Medical and Veterinary Mycology, 29 (2), 6372

Six Phase I/II clinical trials enrolling approximately 900 participants confirmed an excellent safety profile with no serious adverse events attributed to the compound

Corsini EM, Wang Q, Tran HT, Mitchell KG, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Swisher SG , Vaporciyan AA, Walsh GL, Reuben A, Vasquez ME, Bernatchez C, Wang J, Cascone T, Zhang J, Heymach JV, Gibbons DL, Haymaker CL, Sepesi B