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We have strong data in discordant populations [4], [5]

10.1016/j.tmrv.2019.08.004 30 EsmonC

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Standard Rest Periods: After 10-day cycle: 20-30 days rest After 20-day cycle: 40-60 days rest After extended cycles: 90+ days rest During rest periods, researchers can analyze collected data, plan protocol modifications, and prepare for subsequent cycles