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It is further theorized that these high calcium concentrations within the cell could prompt the secretory vesicles in the somatotroph cells to release growth hormone into the bloodstream

Morelli MP, Overman MJ, Vilar Sanchez E, Morris VK, Shureiqi I, Garrett CR, Fogelman DR, Raghav KPS, Kee BK, Deaton L, Eng C, Wolff RA, Sebisanovic D, Siew L, Zapanta A, Mei G, Schiller B, Eltoukhy H, Talasaz AA, Kopetz S

When stomach acid hits the esophageal tissue, it triggers the production of reactive oxygen species (ROS)

Certain fungal or bacterial skin infections can cause inflammation that triggers excess melanin production as a protective response