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Studies in the PCOSIR rat model demonstrate that metformin reduces ROS levels, resulting in improved mitochondrial function and insulin sensitivity and upregulated PI3K and AKT gene expression (Rabah et al., 2023)

Maiti A, Rausch CR, Cortes JE, Pemmaraju N, Daver NG, Ravandi F, Garcia-Manero G, Borthakur GM, Naqvi K, Ohanian M, Short NJ, Alvarado Y, Benton CB, Kadia TM, Takahashi K, Yilmaz M, Jain N, Kornblau SM , Sasaki K, Andreeff M, Bose P, Ferrajoli A, Issa GC, Jabbour E, Masarova L, Rytting ME, Thompson PA, Wang SA, Konoplev S, Chen Z, Goswami M, Maduike R, Guerrero JA, Zhang Q, Cavazos A, Ma H, Bivins CA, Wade A, Adewale SL, Tse S, Thomas R, Vaughan K, Pierce SA, Ning J, Qiao W, Welch JS, Patel KP, Kantarjian HM, Konopleva MY, DiNardo CD

Researchers also suggest that BPC-157 increases blood flow in the body by increasing the production and release of nitric oxide (NO)

Exocrine pancreatic insufficiency loss of intrinsic factor

Mandell DS, Thompson WW, Weintraub ES, Destefano F, Blank MB