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Techniques such as ultrasound, radiofrequency, lasers, chemical permeation enhancers, and microneedling have been developed to enhance delivery [95]

Moreover, excessively high calcium levels in mitochondria induce the activation of calmodulin-dependent protein kinase II delta (CaMKII) and the RIPK3/MLKL cascade, while overexpression of MFN2 significantly inhibits necroptosis [169]