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Agents that induce the formation of ROS can affect redox homeostasis by upregulating antioxidant enzymes, particularly glutathione peroxidase and enzymes involved in glutathione recycling and biosynthesis [12, 16, 21, 22, 3741, 115, 116, 164, 169, 170, 175177]

SayedEBakhiteEHassanienRFarhanNAlyHMorsySet alNovel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

Mol Psychiatry 27 , 26592673 (2022)

There is the assumption that the loading dose made you better, and then the maintenance dose keeps you better, no matter the cause of the original deficiency, no matter the original level and most importantly to us: no matter the range, severity and frequency of your symptoms and how that impacts on your life