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In certain embodiments, any controlled release otic formulation or composition described herein increases the exposure of a therapeutic agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition

This makes them unique in providing cognitive enhancements while also potentially reducing anxiety 6

Formed in the liver and kidneys, L-Carnitine is created from amino acids Lysine and Methionine

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Normally, it opens to let food pass and closes to prevent acid from moving upward