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Thus, the plasma level of reduced glutathione even after administration in high doses is insignificant (C max in plasma, 1 nmol / ml 5 min after administration of 600 mg), while cysteine metabolite levels are higher (C max in blood plasma 17 nmol / ml)

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Pyocyanin also initiates neutrophil extracellular trap (NET) formation (Rada et al., 2013) and aberrant NET release triggered by pyocyanin-mediated intracellular ROS production directly damages host tissues and has been linked to the severity of many diseases including CF (Rada et al., 2013)

Additionally, clinical pregnancy rates, live birth rates, and singleton live birth rates are significantly lower in patients with DOR [9]