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In summary, the hyperglycemic state inherent to diabetes leads to ECD and inflammatory responses that persist even after normoglycemia restoration, due to epigenetic modifications [175]

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[DOI] [PubMed] [Google Scholar] Perez DM, Karnik SS

The production of IL-2 and IL-18 by inflammatory epidermal dendritic cells (IDEC) or eosinophils and the subsequent activation of Th1 cells facilitate the transition to the chronic inflammatory phase with the production of TNF, IL-2, IL-12, INF (52)

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