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The study also showed very little benefit from cutting back from two packs a day to half a pack a day, said Judith Prochaska, a researcher at Stanford University in California who wasn't involved in the study

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Although UPR is a compensatory cellular response that reduces protein synthesis and enhances protein folding and degradation, UPR also contributes to lung cell apoptosis and lung inflammation during excessive ER stress [43,44,45,46,47]