If your serum has changed colour, developed sediment, or exceeded its stability window, discard it
Of course, you can also consider using a non-hormonal option, like the copper IUD or condoms, if you dont want to worry about drug interactions (condoms are also the only method that protects against STIs)
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Dvorakova, Marketa, et al
Acknowledgements This work was supported by the National Natural Science Foundation of China (82073313 to D.L.), the joint project of the State Administration of Traditional Chinese Medicine and Health Commission of Shandong Province (GZY-KJS-SD-2023-094), the Traditional Chinese Medicine Special Project of Binzhou Medical University Affiliated Traditional Chinese Medicine Hospital (2023ZYZX02) and the 2023 Qilu Biancang Traditional Chinese Medicine Talent Cultivation Project (to D.L.)