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Subjective effects and PK parameters were calculated using a SAS program which follow the same algorithm of NCA as that implemented in WinNonlin Professional (Version 8.0, Pharsight Corporation, A Certara Company, St

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Major hallmarks often observed in early AMD are thickening of the Bruchs membrane, reduced choroidal blood flow, and the appearance of drusen, deposits of metabolic products accumulating between the RPE and Bruchs membrane [6, 8,9,10]