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ACTL6A regulates GCLC in transcriptional level via NRF2 The synthesis of -GC is catalyzed by GCL, which is the rate-limiting enzyme in the GSH biosynthesis pathway

By integrating mechanistic and pharmacological insights, this work aims to establish a comprehensive theoretical framework for advancing SIRT1-based therapeutic strategies in MASLD

Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies