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Compared to normal fibroblasts, cancer-associated fibroblasts (CAFs) show increased glutamine production and release, which can raise the glutamine content in the TME [81] (Fig

Glutamine, piperine, and citrulline were also increased, reflecting metabolic adaptation to stress

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However, until more research is available, the safest approach remains to listen to your body and consult a healthcare professional before using them togetherespecially if you have any underlying health conditions or are taking medication

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